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At GMP facility Mahidol universityi in Thiland 2006.

Name: Takeshi Omasa
Year of Birth :1963

Link to Short CV


Professor, Department of Material and Life Science, Graduate School of Engineering, Osaka University

Visiting Professor, Institute of Science and Technology, Tokushima University

Education

B.S.: Dep. of Fermentation Technology, Faculty of Eng., Osaka Univ.(1986)
M.S.: Dep. of Fermentation Technology, Graduate School of Eng., Osaka Univ.(1988)
Ph.D.: Dep. of Fermentation Technology, Graduate School of Eng., Osaka Univ.(1992)


Ph.D.Thesis: A Biochemical Engineering Approach for Monoclonal Antibody Production Using Hybridoma Cell Cultivation (under Prof.Suga)

Affiliation:
Assistant Professor, Department of Biotechnology, Faculty of Engineering, Osaka University (1992)
Assistant Professor, Department of Biotechnology, Graduate School of Engineering, Osaka University (1995-2005)
Associate Professor, Department of Biotechnology, Graduate School of Engineering, Osaka University (2005-2010)
Professor, Institute of Science and Technology, The University of Tokushima (2010-2015)
Professor, Department of Material and Life Science, Graduate School of Engineering, Osaka University (2015-)


Visiting Scientist, Dept of Biomedical Engineering, Chemical Engineering, University of Rochester (NY) (1998-1999)
Visiting Scientist, Tissue Engineering Center, National Institute of Advanced industrial Science and Technology (AIST) (2002-2006)
Guest Professor, Department of Biotechnology, Graduate School of Engineering, Osaka University (2010-2015)
Visiting Professor, Institute of Science and Technology, Tokushima University (2015-)



Research Field:
Biochemical Engineering
Mammalian Cell and Cell Culture Engineering
Artificial Organs and Tissue Engineering

Recent Research Work
CHO genome project: The genome analysis of Chinese hamster Ovary (CHO) cells
Construction of chromosome marker for CHO cell.
Control of glycosylation in biopharmaceutical production: Especially focused on Scale-up.
Metabolic Engineering at CHO cell line.


Enjoy doing in spare time: Swimming, Computer, Sightseeing



Academic Activities:

Awards: Terui Award (in the field of biochemical engineering) from the Society for Biotechnology, JAPAN (2004)

Excellent Paper Award from the Society for Biotechnology, JAPAN (2002,2015)

Selected Presentation and Papers 4. Takeshi Omasa, Ken-ichi Higashiyama, Suteaki Shioya, Ken-ichi Suga "Effect of lactate concentration on hybridoma culture in lactate-controlled fed-batch operation" Biotechnology and Bioengineering, Vol. 39, No.5, pp.556-564 (1992)

13. Takeshi Omasa, Masaki Kobayashi, Toshio Nishikawa, Suteaki Shioya, Ken-ichi Suga, Syo-ichi Uemura, Yasuo Kitani, and Yoshio Imamura "Enhancement of antibody production by growth factor addition in perfusion and hollow-fiber culture systems" Biotechnology and Bioengineering, Vol. 48, No.6, pp.673-680 (1995)

41. Tomohiro Yoshikawa, Fumi Nakanishi, Seima Itami, Daisuke Kameoka, Takeshi Omasa*, Yoshio Katakura, Michimasa Kishimoto and Ken-ichi Suga "Evaluation of stable and highly productive gene amplified CHO cell line based on the location of amplified gene" Cytotechnology Vol.33, Nos.1-3, pp.37 -46 (2000)


42. Tomohiro Yoshikawa, Fumi Nakanishi, Yuki Ogura, Daisuke Oi, Takeshi Omasa*, Yoshio Katakura, Michimasa Kishimoto and Ken-ichi Suga "Amplified gene location in chromosomal DNA affected recombinant protein production and stability of amplified genes" Biotechnology Progress, Vol.16, No. 5, pp.710 -715 (2000)

46. Shin Enosawa, Toshiyuki Mukaiyama, Tomoyuki Miyashita, Xiao-Kang Li, Seiichi Suzuki, Hiroshi Amemiya, Toshiharu Matsumura, Takeshi Omasa, and Kenichi Suga "Application of circulatory flow bioreactor for long-term and large-scale culture of glutamine synthetase transduced CHO cells and its ammonia removal activity with an aim of development for a bioartificial liver assist system" Journal of Artificial Organ Vol.4 pp. 61-66 (2001)

47. Takeshi Omasa, Yi-Guang Chen, Athanassios Mantalaris, and J.H.David Wu "A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP1g1/PLM/MAT8 family of transmembrane proteins" Biochemica et Biophysica Acta, Vol. 1517, No.2, pp.307 - 310 (2001)

51. Tomohiro Yoshikawa, Fumi Nakanishi, Yuki Ogura, Daisuke Oi, Takeshi Omasa*, Yoshio Katakura, Michimasa Kishimoto, Ken-ichi Suga "Flow cytometry: An improved method for the selection of highly productive gene-amplified CHO cells using flow cytometry" Biotechnology and Bioengineering, Vol. 74: 435-442, (2001).

62. Takeshi Omasa, Michimasa Kishimoto, Masaya Kawase, Kiyohito Yagi "An attempt at decision making in tissue engineering: Reactor evaluation using the analytic hierarchy process (AHP)" Biochemical Engineering Journal, Vol. 20, No.2-3, pp.173-179 (2004)

68. Takeshi Omasa, Kazumi Kim, Shinya Hiramatsu, Yoshio Katakura, Michimasa Kishimoto, Shin Enosawa and Hisao Ohtake"Construction and evaluation of drug-metabolizing cell line for bioartificial liver support system" Biotechnology Progress Vol. 21, pp.161-167 (2005)

8. Takeshi Omasa "Gene amplification and its application in cell and tissue engineering"
Journal of Bioscience and Bioengineering, Vol. 94, No.6 pp.600-605 (2002)

1. U.S. Patent No. 6,562,571; May 13, 2003. US　2005/0164364 A1 Jul.28,2005, Inventor; J.H. David Wu, Takeshi Omasa, Athanassios Mantalaris, Yi-Guang Chen, Ying-Chuech Ysai, Title; human heme-regulated initiation factor 2.alpha kinase

1. Takeshi Omasa, Hidenori Yano, Yihua Cao, Mihoko Kajita,Yuki Ogura,Tomohiro Yoshikawa, and Hisao Ohtake "Suitable chromosomal location for dyhdroforate reductase gene amplification in Chinese hamster ovary cell" In; Engineering Conference International: Cell Culture Engineering X, P-38, p.130, April 23-28, 2006, Whistler, BC, Canada

2. Takeshi Omasa "Chromosome targeting for biopharmaceutical production" In; 7th Northeastern Asia Symposium on Biotechnology , Proceeding book p.41-42 , November 7-9, 2005, Gyeongju, Korea (Invited lecture, Korea Science and Engineering Foundation, & JSPS)

3. Takeshi Omasa, Masaya Kawase, Shin Ennosawa and Hisao Ohtake "Bioartificial liver support system -construction and evaluation-" In international symposium and annual meeting of Korean Society for Biotechnology and Bioengineering, Proceeding book p.102 ,A205, Octorber 13-15, 2004, Cheongju, Korea (Invited lecture, Supported by organizer)

4. Takeshi Omasa, Masaya Kawase, Shin Enosawa "Reactor evaluation for bioartificial liver support system - BAL clearance and AHP analysis" In; Engineering Conference International: Cell Culture Engineering VIIII, Session D, Stem cell and Tissue Engineering, No. P.I.D.5., p.69, March 7-12, 2004, Cancun, Mexico

4. Takeshi Omasa "Rapid construction of CHO cell line based on chromosome targetting"　In;19th annual and international meeting of Japanese Association for Animal Cell Technology (JAACT '06) S6-6, abstract p.66 September 25-28, Kyoto, Japan (2006)

9. Takeshi Omasa, Tetsuji Hayashi, Shinsuke Onishi, Tadaaki Hashimoto, Michimasa Kishimoto, Tomohiro Yoshikawa, Masato Miyake, Hisao Ohtake "Construction of suitable cell line and system for cell based simulator for drug evaluation" In; 11th Young Asian Biochemical Engineers' Community (YABEC) 2005, Beijing China, PP-33, Oct. 24-26, Abstract p.71 (2005) (Most excellent poster presentation award)

e-mail address: omasa atmark bio.eng.osaka-u.ac.jp