PUBLICATIONS
Hisao Ohtake
Professor
Department of Biotechnology
Graduate School of Engineering
Education
| B.A., 1973 | Chemical Engineering, University of Tokyo, Tokyo, Japan. |
| M.S., 1975 | Biochemical Engineering, University of Tokyo, Tokyo, Japan. |
| Dr., 1978 | Biochemical Engineering, Osaka University, Osaka, Japan. |
Professional/Research Appointments
| 2003-present | Professor, Department of Biotechnology, Osaka University, Osaka, Japan |
| 1990-2003 | Professor, Department of Molecular Biotechnology, Hiroshima University, Hiroshima, Japan |
| 1983-1989 | Associate Professor, University of Tokyo, Tokyo, Japan |
| 1986-1987 | Research Associate, University of Illinois College of Medicine, Chicago, Il., U.S.A. |
| 1985-1986 | Visiting Associate Professor, Washington University,St. Louis, Mo., U.S.A. |
| 1980-1983 | Associate Professor, Shimane University, Shimane, Japan |
| 1978-1980 | Assistant Professor, Shimane University, Shimane, Japan |
Academic committees and Boards
| - Chairman, Division of Biochemical Engineering, The Society of Chemical Engineers, Japan, | 2002-2006 |
| - President, Japan Society for Environmental Biotechnology, | 2005-2007 |
| - Chairman, Phosphorus Recycling Promotion Council of Japan, | 2008- |
| - Editor, FEMS Microbiology Reviews, | 2001-2003 |
| - Editor, Applied Microbiology and Biotechnology, | 2000-2002 |
| - Editor-in-Chief of Journal of Bioscience and Bioengineering, | 2007-2011 |
Awards
| Japan Bioindustry Association Award | 2008 |
| Japan Society for Environmental Biotechnology Award | 2010 |
| Society for Biotechnology, Japan Award | 2013 |
ORIGINAL PAPERS
| ORIGINAL PAPERSList of selected papers JUMP TO 1990- JUMP TO 2000- JUMP TO 2005- JUMP TO 2010- |
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| 1. | Aiba, S., Okada, M., Ohtake, H., Sudo, R. and Mori, T. Simulation of BOD and DO balance in a shallow and polluted river (I) (in Japanese). J. Jpn. Sewage Works Assoc. 12: No.131, 33-38 (1975). |
| 2. | Aiba, S., Okada, M., Ohtake, H., Sudo, R. and Mori, T. Simulation of BOD and DO balance in a shallow and polluted river (II) (in Japanese). J. Jpn.Sewage Works Assoc. 12: No.132, 26-37 (1975). |
| 3. | Sudo, R., Mori,T., Ohtake, H., Okada, M. and Aiba, S. Algal growth potential of secondary treated sewage waters (in Japanese). J. Jpn. Sewage Works Assoc. 12: No.133, 22-30 (1975). |
| 4. | Aiba, S., Ohtake, H. and Sudo, R. Simulation of BOD and DO balance in a shallow and polluted river (III) (in Japanese). J. Jpn. Sewage Works Assoc. 14: No.155, 47-53 (1977). |
| 5. | Aiba, S. and Ohtake, H. Simulation of PO4-P balance in a shallow and polluted river. Water Research 11: 159-164 ( 1977 ) |
| 6. | Sudo, R., Ohtake, H., Aiba, S. and Mori, T. Some ecological observations on the decomposition of periphytic algae and aquatic plants. Water Research 12: 179-184 ( 1978 ). |
| 18. | Ohtake, H., Takahashi, K., Tsuzuki, Y. and Toda, K. Uptake and release of phosphate by a pure culture of Acinetobacter calcoaceticus. Water Research 19: 1587-1594 ( 1985 ). |
| 22. | Ohtake, H., Cervantes, C. and Silver, S. Decreased chromate uptake in Pseudomonas fluorescens carrying a chromate resistance plasmid. J. Bacteriol. 169: 3853-3856 ( 1987 ). |
| 26. | Cervantes, C. and Ohtake, H. Plasmid-determined resistance to chromate in Pseudomonas aeruginosa. FEMS Microbiol. Lett. 56:173-176 ( 1988 ). |
| 31. | Komori, K., Wang, P., Toda, K. and Ohtake, H. Factors affecting chromate reduction in Enterobacter cloacae. Appl. Microbiol. Biotechnol. 31: 567-570 ( 1989 ). |
| 32. | Park, Y., Ohtake, H., Fukaya, M., Okumura, H., Kawamura, Y. and Toda, K. Effects of dissolved oxygen and acetic acid concentrations on acetic acid production in continuous culture of Acetobacter aceti. J. Ferment. Bioeng. 68: 96-101 ( 1989 ). |
| 35. | Park, K., Ohtake, H., Toda, K., Fukaya, M., Okuma, H. and Kawamura, Y. Acetic acid production using a fermenter equipped with a hollow fiber filter module. Biotechnol. Bioeng. 33: 918-923 ( 1989 ). |
| 36. | Wang, P., Mori, T., Komori, K., Sasatsu, M., Toda, K. and Ohtake, H. Isolation and characterization of an Enterobacter cloacae strain that reduces hexavalent chromium under anaerobic conditions. Appl. Enviorn. Microbiol. 55: 1665-1669 ( 1989 ). |
| 41. | Fujii, E., Toda, K. and Ohtake, H. Fed-batch culture of Enterobacter cloacae strain HO1 to detoxify hexavalent chromium. J. Ferment. Bioeng. 69: 365-367 ( 1990 ). |
| 1990- | JUMP TO TOP OF ORIGINAL PAPERS |
| 43. | Ohtake, H., Fujii, E. and Toda, K. Reduction of toxic chromate in an industrial effluent by use of a chromate-reducing strain of Enterobacter cloacae. Environ. Technol. Lett. 11: 663-668 (1990). |
| 44. | Toda, K., Miyake, M. and Ohtake, H. Enhanced oxygen absorption in shallow-flow surface culture. J. Ferment. Bioeng. 70:114-118 (1990). |
| 47. | Ohtake, H., Fujii, E. and Toda, K. Biological reduction of hexavalent chromium: kinetic aspects of chromate reduction by Enterobacter cloacae HO1. Biocatalysis 4:227-235 ( 1990 ). |
| 49. | Komori, K., Rivas, A., Toda, K. and Ohtake, H. A method for removal of toxic chromium by use of dialysis sac cultures of a chromate-reducing strain of Enterobacter cloacae. Appl. Microbiol. Biotechnol. 33: 117-119 ( 1990 ). |
| 50. | Cervantes, C., Ohtake, H., Chu, L., Misra, T.K. and Silver, S. Cloning, nucleotide sequence, and expression of the chromate resistance determinant of Pseudomonas aeruginosa plasmid pUM505. J. Bacteriol. 172: 287-291 ( 1990 ). |
| 51. | Komori, K., Wang, P., Rivas, A., Toda, K. and Ohtake, H. Biological removal of toxic chromium using an Enterobacter cloacae strain that reduces chromate under anaerobic conditions. Biotechnol. Bioeng. 35: 951-954 ( 1990 ). |
| 52. | Wang, P., Mori, T., Toda, K. and Ohtake, H. Membrane-associated chromate reductase activity from Enterobacter cloacae. J. Bacteriol. 172: 1670-1672 ( 1990 ). |
| 58. | Nikata, T., Sumida, K., Kato, J. and Ohtake, H. Rapid method for analyzing bacterial behavioral responses to chemical stimuli. Appl. Environ. Microbiol. 58:2250-2254 ( 1992 ). |
| 59. | Kato, J., Ito, A., Nikata, T. and Ohtake, H. Phosphate taxis in Pseudomonas aeruginosa. J. Bacteriol. 174:5149-5151 ( 1992 ). |
| 61. | Yamamoto, K., Kato, J., Yano, T. and Ohtake, H. Kinetics and modeling of hexavalent chromium reduction in Enterobacter cloacae. Biotechnol. Bioeng. 41:129-133 (1993). |
| 65. | Kato, J., Yamada, K., Muramatsu, A., Hardoyo and Ohtake, H. Genetic improvement of Escherichia coli for the enchanced biological removal of phosphate. Appl. Environ. Microbiol. 59: 3744-3749 (1993). |
| 64 | Kato, J., Yamamoto, T., Yamada, K. and Ohtake, H. Cloning, sequence and characterization of the polyphosphate kinase-encoding gene (ppk) of Klebsiella aerogenes. Gene 137: 237-242 (1993). |
| 68. | Kato, J., Sakai, Y., Nikata, T., and Ohtake, H. Cloning and characterization of a Pseudomonas aeruginosa gene involved in the negative regulation of phosphate taxis. J. Bacteriol. 176: 5874-5877 (1994). |
| 70. | Masduki, A., Nakamura, J., Ohga, T., Umezaki, R., Kato, J. and Ohtake, H. Isolation and characterization of chemotaxis mutants and genes of Pseudomonas aeruginosa. J. Bacteriol. 177:948-952 (1995). |
| 72. | Kuroda, A., Kumano, T., Taguchi, K., Nikata, T., Kato, J. and Ohtake, H. Molecular cloning and characterization of a chemotactic transducer gene in Pseudomonas aeruginosa. J. Bacteriol. 177:7019-7025 (1995). |
| 73. | Nikata, T., Sakai, Y., Shibata, K., Kato, J., Kuroda, A. and Ohtake, H. Molecular analysis of the phosphate transport (pst) operon of Pseudomonas aeruginosa. Mol. Gen. Genet. 250: 692-698 (1996). |
| 77. | Taguchi, K., Fukutomi, H., Kuroda, A., Kato, J. and Ohtake, H. Genetic identification of chemotactic transducers for amino acids in Pseudomonas aeruginosa. Microbiology 143:3223-3229 (1997). |
| 83. | Kato, J., Nakamura, T., Kuroda, A. and Ohtake, H. Cloning and characterization of chemotaxis genes in Pseudomonas aeruginosa. Biosc. Biochem. Biotechnol. 63: 155-161 (1999). |
| 86. | Kuroda, A., Tanaka, S., Ikeda, T., Kato, J., Takiguchi, N. and Ohtake, H. Inorganic polyphosphate kinase is required to stimulate protein degradation and adapt to amino acid starvation in Escherichia coli. Proc. Natl. Acad. Sci. 96: 14264-14269 (1999). |
| 2000- | JUMP TO TOP OF ORIGINAL PAPERS |
| 87. | Hirota, R., Yamagata, A., Kato, J., Kuroda, A., Ikeda, T., Takiguchi, N.
and Ohtake, H. Physical map location of the multicopy genes coding for ammonia monooxygenase
and hydroxylamine oxidoreductase in the ammonia-oxidizing bacterium Nitrosomonas sp. strain ENI-11. J. Bacteriol. 182: 825-828 (2000). |
| 89. | Yamagata, A., Hirota, R., Kato, J., Kuroda, A., Ikeda, T., Takiguchi, N.
and Ohtake, H. Mutational analysis of the multicopy hao gene coding for hydroxylamine oxidoreductase in the ammonia-oxidizing bacterium Nitrosomonas sp. strain ENI-11. Biosc. Biochem. Biotechnol. 64: 1754-1757 (2000). |
| 90. | Wu, H., Kato, J., Kuroda, A., Ikeda, T., Takiguchi, N. and Ohtake, H. Identification and Characterization of Two Chemotactic Transducers for Inorganic Phosphate in Pseudomonas aeruginosa. J. Bacteriol. 182: 3400-3404 (2000). |
| 91. | Lee, S., Kato, J., Takiguchi, N., Kuroda, A., Ikeda, T., Mitsutani, A.
and Ohtake, H. Involvement of an extracellular protease in the algicidal activity of the marine bacterium Pseudoalteromonas sp. strain A28. Appl. Environ. Microbiol. 66: 4334-4339 (2000). |
| 92. | Kuroda, A., Kunimoto, H., Morohoshi, T., Ikeda, T., Kato, J., Takiguchi,
N.,Miya, A. and Ohtake, H. Evaluation of phosphate removal from water by immobilized phosphate-binding protein PstS. J. Biosc. Bioeng. 90: 688-690 (2000). |
| 93. | Kato, J., Nagata, C., Yang, L., Kuroda, A., Ikeda, T., Takiguchi, N. and
Ohtake, H. Isolation and characterization of the Enterobacter cloacae cheR mutant defective in phosphate taxis. Biosc. Biochem. Biotechnol. 65: 456-458 (2001). |
| 94. | Tajima, T., Watanabe, N., Kogawa, Y., Takiguchi, N., Kato, J., Ikeda, T.,
Kuroda, A. and Ohtake, H. Chemotaxis by the nematode Caenorhabditis elegans toward quinine hydrochloride and cycloheximide. J. Biosc. Bioeng. 91: 322-324 (2001). |
| 95. | Ikeda, T., Kajiyama, K., Kita, T., Takiguchi, N., Kuroda, A., Kato, J.
and Ohtake, H. The optical resolution of synthetic N-acyl-homoserine lactone autoinducers and their analogues. Chem. Lett. 314-315 (2001). |
| 96. | Kuroda, A., Nomura,K., Ohtomo R., Kato, J., Ikeda, T., Takiguchi, N., Ohtake, H. and Kornberg, A. Inorganic polyphosphate: a molecular tag to identify ribosomal proteins for degradation by Lon protease in E. coli. Science 293: 705-708 (2001). |
| 97. | Tanaka, S., Kuroda, A., Kato, J., Ikeda, T., Takiguchi, N. and Ohtake, H. A sensitive method for detecting AMP by utilizing polyphosphate-dependent ATP generation and bioluminescence reactions. Biochem. Eng. J. 9: 193-197 (2001). |
| 98. | Takiguchi N., Tajima T., Asayama K., Ikeda T., Kuroda A., Kato J. and Ohtake, H. Behavioral responses of the ciliated protozoan Paramecium caudatum to 2,4- dichlorophenoxyacetic acid and its analogues. J. Biosci. Bioeng. 93: 416-420 (2002). |
| 99. | Morohoshi T., Maruo T., Shirai Y., Kato J., Ikeda T., Takiguchi N., Ohtake H. and Kuroda A. Accumulation of inorganic polyphosphate in phoU mutants of Escherichia coli and Synechocystis sp. sain PCC6803. Appl. Environ. Microbiol., 68: 4107-4110 (2002). |
| 100. | Kuroda A., Takiguchi N., Gotanda T., Nomura K., Kato J., Ikeda T., Ohtake H. A simple method to release polyphosphate from activated sludge for phosphorus reuse and recycling. Biotechnol. Bioeng. 78: 333-338 (2002). |
| 101. | Lee S., Kato J., Nakashima K., Kuroda A., Ikeda T., Takiguchi, N., and
Ohtake H. Cloning and characterization of extracellular metal protease gene of the algicidal marine bacterium Pseudoalteromonas sp. strain A28. Biosci. Biotechnol. Biochem. 66: 1366-1369 (2002). |
| 102. | Hirota R., Kato J., Morita H., Kuroda A., Ikeda T., Takiguchi, N. and Ohtake
H. Isolation and characterization of cbbL and cbbS genes encoding form I ribulose-1,5- bisphosphate carboxylase/oxygenase large and small subunits in Nitrosomonas sp. strain ENI-11. Biosci. Biotechnol. Biochem. 66: 632-635 (2002). |
| 103. | Tsuji, T., Sakane, A., Fukuda, O., Kaneko, M. and Ohtake, H. Bio-mimetic control of mobile robots based on a model of bacterial chemotaxis (in Japanese). Trans. JSME C68: 2687-2694 (2002). |
| 104. | Tsuji, T., Hashigami, K., Kaneko, M. and Ohtake, H. Emerging chemotaxis of virtual bacteria using genetic algorithm (in Japanese). Trans. IEE of Japan, 122-C: 201-207 (2002). |
| 105. | Shitashiro M., Jkato J., Fukumura T., Kuroda A., Ikeda T., Takiguchi N.
and Ohtake H. Evaluation of bacterial aerotaxis for its potential use in detecting the toxicity of chemicals to microorganisms. J. Biotechnol. 101: 11-18 (2003). |
| 106. | Morohoshi, T., Yamashita, T., Kato, J., Ikeda, T., Takiguchi, N., Ohtake, H., and Kuroda, A. A method for screening polyphosphate-accumulating mutants which remove phosphate efficiently from synthetic wastewater. J. Biosc. Bioeng. 95:637-640 (2003). |
| 107. | Ikeda T., Inoue Y., Suehiro A., Ikeshoji H., Ishida T., Takiguchi N., Kuroda
A., Kato J. and Ohtake H. The Effects of Cyclodextrins on Autoinducer Activities of Quorum Sensing in Pseudomonas aeruginosa. J. Inclusion Phenomena, 44:381-382 (2003). |
| 108. | Takiguchi, N., Kuroda, A., Kato, J., Nukanobu, K. and Ohtake, H. Pilot plant tests on the novel process for phosphorus recovery from municipal wastewater. J. Chem. Eng. Japan, 36:1143-1146 (2003). |
| 109. | Tajima, T., Takiguchi, N., Kato, J., Ikeda, T., Kuroda, A. and Ohtake, H. Mutants of the nematode Caenorhabditis elegans that are defective specifically in their attraction to cycloheximide. J. Biosc. Bioeng. 96:149-153 (2003). |
| 110. | Tanaka, S., Lee, S., Hamaoka, K., Kato, J., Takiguchi, N., Nakamura, K.,
Ohtake, H. and Kuroda, A. Strictly polyphosphate-dependent glucokinase in a polyphosphate-accumulating bacterium Microlunatus phosphovorus. J. Bacteriol. 185:5654-5656 (2003). |
| 111. | Hong, C.-S., Shitashiro, M., Kuroda, A., Ikeda, T., Takiguchi, N., Ohtake, H., and Kato, J. Genetic identification of chemotaxis proteins and transducers for aerotaxis in Pseudomonas aeruginosa. FEMS Microbiol. Lett. 231: 247-252 (2004). |
| 112. | Hong, C.-S., Kuroda, A., Ikeda, T., Takiguchi, N., Ohtake, H., and Kato, J. The aerotaxis transducer gene aer, but not aer-2, is transcriptionally regulated by the anaerobic regulator ANA in Pseudomonas aeruginosa. J. Biosc. Bioeng. 97: 184-190 (2004). |
| 113. | Yang, L., Kuroda, A., Ikeda, T., Takiguchi, N., Ohtake, H., and Kato, J. Characterization of pEC01, a novel plasmid required for phosphate taxis in Enterobacter cloacae IFO3320. Microbes Environ. 19:45-52 (2004). |
| 114. | Takiguchi, N., Kishno, M., Kuroda, A., Kato, J., and Ohtake, H. A laboratory-scale test of anaerobic digestion and methane production after phosphorus recovery from waste activated sludge. J. Biosc. Bioeng., 97:365-368 (2004). |
| 115. | Sato, T., Kato, J., Takiguchi, N., Ohtake, H., and Kuroda, A. Development of ultrasensitive bioluminescence assay of ATP: detection of a single bacterial cell. Biosci. Biotechnol. Biochem.,68:1216-1220 (2004). |
| 116. | Nomura, K., Kato, J., Takiguchi1, N., Ohtake, H., and Kuroda, A. Effects of inorganic polyphosphate on the proteolytic and DNA-binding activities of Lon in Escherichia coli. J. Biol. Chem.,279:34406-34410 (2004). |
| 2005- | JUMP TO TOP OF ORIGINAL PAPERS |
| 117. | Hong, C.-S., Kuroda, A., Takiguchi, N., Ohtake, H. and Kato, J. Expression of Pseudomonas aeruginosa aer-2, One of Two Aerotaxis Transducer Genes, Is Controlled by RpoS. J. Bacteriol., 187:1533-1535(2005). |
| 118. | Konishi, M., Kishimoto, M., Tamesui, N., Omasa, T., Shioya, S., and Ohtake, H. theseparation of oil from an oil-water-bacteria mixture using a hydrophobic tubular membrane. Biochem. Eng. J., 24: 49-54 (2005). |
| 119. | Konishi, M., Kishimoto, M., Omasa, T., Katakura, Y., Shioya, S., and Ohtake, H. Effect of sulfur sources on specific desulfurization activity of Rhodococcus erythropolis KA2-5-1 in exponential fed-batch culture J.Biosc. Bioeng., 99:259-263(2005) |
| 120. | Na, K.-S., Kuroda, A.,Takiguchi, N., Ikeda, T., Ohtake, H., and Kato, J. Isolation and characterization of benzene-tolerant Rhodococcus opacus strains J. Biosc. Bioeng., 99: 378-382 (2005). |
| 121. | Na, K.-S., Kuroda, A.,Takiguchi, N., Ikeda, T., Ohtake, H., and Kato, J. Development of a genetic transformation system for benzene-tolerant Rhodococcus opacus strains. J. Biosc. Bioeng., 99: 408-414 (2005). |
| 122. | Omasa, T., Kim, K., Hiramatsu, S., Katakura, Y., Kishimoto, M., Enosawa,
S., and Ohtake, H. Construction and evaluation of drug-metabolizing cell line for bioartificial liver support system. Biotechnol. Prog., 21:161-167 (2005) . |
| 123. | Faizal, I., Dozen, K., Hong, C.-S., Kuroda, A., Takiguchi, N., Ohtake, H.. Takeda, K., Tsunekawa H., and Kato, J. Isolation and characterization of solvent tolerant Pseudomonas putida strain T-57, and its application to biotransformation of toluene to cresol in a two-phase (organic-aqueous) system. J. Ind. Microbiol. Biotechnol., 32: 542-547 (2005). |
| 124. | Hirano, A., Tsuji, T., Takiguchi, N., and Ohtake H. Modeling of the membrane potential change of Paramecium for mechanical stimuli. Trans. SICE, 41:351-357 (2005). |
| 125. | Shitashiro, M., Tanaka, H., Hong, C.-S., Kuroda, A., Takiguchi, N., Ohtake,
H., and Kato, J. Identification of Chemosensory Proteins for Trichloroethylene in Pseudomonas aeruginosa. J. Biosc. Bioeng., 99: 396-402 (2005). |
| 126. | Suzuki, M., Goto, T., and Tsuji, T., and Ohtake, H. A dynamic body model of the nematode C. elegans with neural oscillators. J. Robot. Mechatron.,17: 318-326 (2005). |
| 127. | Suzuki, M., Tsuji, T., and Ohtake H. A model of motor control of the nematode C. elegans with neuronal circuits. Computer Intelligence Techniques in Bioinformatics Artificial Intelligence in Medicine, .35: 75-86 (2005). |
| 128. | H. Kurata, H. El-Samad, R. Iwasaki, H. Ohtake, J. C. Doyle, I. Grigorova,C. A. Gross, M. Khammash Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System. PLoS Comput. Biol., 2: 663-675 (2006). |
| 129. | Nomura, K., Kato, J., Takiguchi, N., Ohtake, H., and Kuroda, A. Inorganic polyphosphate stimulates Lon-mediated proteolysis of nucleoid proteins in Escherichia coli. Cell. Mol. Biol., 52: 23-29 (2006). |
| 130. | Hisao Ohtake, Shiho Yamashita, Junichi Kato Development of a new biotechnological basis for improving industrial sustainability of Japan. Eng. Life Sci., 6: 278-284 (2006). |
| 131. | N. Izawa, M. Kishimoto, K. Konishi, T. Omasa, S. Shioya, H. Ohtake. Recognition of Culture State Using Two-dimensional Gel Electrophoresis with an Artificial Neural Network. Proteomics, 6: 3730-3738 (2006). |
| 132. | K. Motomura, N. Takiguchi, H. Ohtake, A. Kuroda Polyamines affect polyphosphate accumulation in Escherichia coli. J. Environ. Biotechnol., 6: 41-46 (2006). |
| 133. | Hirota, R., Kuroda, A., Ikeda, T., Takiguchi, N., Ohtake, H., and Kato, J. Transcriptional Analysis of the multicopy hao gene coding for hydroxylamine oxidoreductase in Nitrosomonas sp. strain ENI-11. Biosci. Biotechnol. Biochem., 70: 1875-1881, 2006. |
| 134. | H.-E. Kim, M. Shitashiro, A. Kurda, N. Takiguchi, H. Ohtake, J. Kato Identification and characterization of the chemotactic transducer in Pseudomonas aeruginosa PAO1 for positive chemotaxis to trichloroethylene. J. Bacteriol.,188: 6700-6702 (2006). |
| 135. | Hirano, A., Tsuji, T., Takiguchi, N., and Ohtake, H. Simulation for chemotactic response of Paramecium using virtual Paramecium. Trans. SICE, 42: 1252-1259 (2006). |
| 136. | Hirano, A., Tsuji, T., Takiguchi, N., and Ohtake, H. Biomimeticcontrol of mobile robots based on the chemotactic response model of Paramecium. Trans. JSME. 73: 2757-2764 (2007). |
| 137. | Yamashita, S., Sameshima, Y., Konishi, M., Kato, J., Kishimoto, M., Honda,
K., Omasa, K., and Ohtake, H. Integrated biooxidation and acid dehydration process for monohydroxylation of aromatics. Process Biochem., 42: 46-51 (2007). |
| 138. | Takiguchi, N., Kishino, M., Kuroda, A., Kato. J., Ohtake, H. Effect of Mineral Elements on Phosphorus Release from Heated Sewage Sludge. Biores. Technol., 98: 2533-2537 (2007). |
| 139. | Yamashita, S. Satoi, M., Honda, K., Samejima, Y., Omasa, T., Kato, J.,
and Ohtake, H. Utilization of hydrophobic bacterium Rhodococcus opacus Strain B-4 as whole-cell biocatalyst in anhydrous organic solvents Appl. Microbiol. Biotechnol., 74: 761-767 (2007). |
| 140. | Ishida, T., Ikeda, T., Takiguchi, N., Kuroda, A., Ohtake, H., Kato, J. Inhibition of quorum sensing in Pseudomonas aeruginosa by N-acyl cyclopentylamides. Appl. Environ. Microbiol., 73: 3183-3188 (2007). |
| 141. | Iwamoto, S., Motomura, K., Shinoda, Y., Urata, M., Kato, J., Takiguchi,
N., Ohtake, H., Hirota, R., and Kuroda, A. Use of an Escherichia coli recombinant producing thermostable polyphosphate kinase as an ATP regenerator to produce fructose 1,6-diphosphate. Appl. Environ. Microbiol., 73: 5676-5678 (2007). |
| 142. | Faizal, I., Ohba, M., Kuroda, A., Takiguchi, N., Ohtake, H., Honda, K., and Kato J. Bioproduction of 3-methylcatechol from toluene in two-phase (organic-aqueous) system by a genetically modified solvent-tolerant Pseudomonas putida strain T-57. J. Environ. Biotechnol., 7: 39-44 (2007). |
| 143. | Soh, Z., Tsuji, T., Takiguchi, N., and Ohtake, H. A Neural Network Model of the Olfactory System of Mice: Simulated Tendency of Attention Behavior. Artificial Life and Robotics, 13: 280-285 (2007). |
| 144. | Ohya, T., Hayashi, T., Kiyama, E., Nishii, H., Miki, H., Kobayashi, K.,
Honda, K., Omasa, T. and Ohtake, H. Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression. Biotechnol. Bioeng. 100: 317-324 (2008). |
| 145. | Takiguchi, N., Okuhara, K., Kuroda, A., Kato, J. and Ohtake, H. Performance of mice in discrimation for liquor odrors: Behavioral evidence for olfactory attention. Chem. Senses, 33: 283-290 (2008). |
| 146. | Kato, J., Kim, H., Takiguchi, N., Kuroda, A., and Ohtake, H. Pseudomonas aeruginosa as a model microorganism for investigation of chemotactic behaviors in ecosystem. J. Biosc. Bioeng., 106: 1-7 (2008) |
| 147. | Honda, K., Yamashita, S., Nakagawa, H., Sameshima, Y., Omasa, T., Kato,
J., and Ohtake, H. Stabilization of water-in-oil emulsion by Rhodococcus opacus B-4 and its application to biotransformation. Appl. Microbiol. Biotechnol., 78: 767-773 (2008). |
| 148. | Soh, Z., Tsuji, T., Suzuki, M., Takiguchi, N. And Ohtake, H. A Neural Network Model of the Olfactory System of Mice: Computer Simulation of the Attention Behavior of mice for some components in an odor. Artificial Life and Robotics, 12: 75-80, 2008 (2008). |
| 149. | Omasa, T., Doi, T., Tanaka, R., Ando, M., Kitamoto, Y., Honda, K., Kishimoto,
M., and Ohtake, H. Control of antithrombion III fucosylation by expressing GDP-fucose transporter siRNA in Chinese hamster ovary cells. J. Biosci. Bioeng., 106: 168-173 (2008). |
| 150. | Sameshima, Y., Honda, K., Kato, J., Omasa, T., and Ohtake, H. Expression of Rhodococcus opacus alkB genes in anhydrous organic solvents. J. Biosci. Bioeng., 106: 199-203 (2008). |
| 151. | Hamada, T., Sameshima, Y., Honda, K., Omasa, T., Kato, J., and Ohtake, H. A comparison of various methods to predict bacterial predilection for organic solvents used as reaction media. J. Biosci. Bioeng., 106:357-362 (2008). |
| 152. | Omasa, T., Takami, T., Ohya, T., Kiyama, E., Hayashi, T., Nishii, H., Miki,
H., Kobayashi, K., Honda,K., and Ohtake, H. Overexpression of GADD34 enhances production of recombinant human antithrombin III in Chinese hamster ovary cells. J. Biosci. Bioeng., 106:568-573 (2008). |
| 153. | Gaoa M.-T., Shimamura, T., Ishida, N., Nagamori, E.,Takahashia, H., Umemoto,
S., Omasa, T. and Ohtake, H. Extractive lactic acid fermentation with tri-n-decylamine as the extractant. Enzy. Microb.Technol., 44:350-354 (2009). |
| 154. | Hamada, T., Maeda, Y., Matsuda, H., Sameshima, Y., Honda, K., Omasa, T.,
Kato, J. and Ohtake, H. Effect of cell-surface hydrophobicity on bacterial conversion of water-immiscible chemicals in two-liquid-phase culture systems J. Biosci. Bioeng., 108: 116-120 (2009). |
| 155. | Omasa, T., Cao, Y., Park, J-Y., Takagi, Y., Yano, H., Honda, K., Asakawa,
S., Shimizu, N., and Ohtake, H. Bacterial artificial chromosome library for genome-wide analysis of Chinese hamster overy cells. Biotechnol. Bioeng., 104: 986-994 (2009). |
| 156. | Vangnai, A., Kongpol, A., Pongtharangkul, T., Kato, J., Honda, K., Ohtake, H. Characterization of an organic-solvent tolerant Brevibacillus agri strain 13 able to stabilize solvent/water emulsion. FEMS Microbiol. Lett., 297: 225-233 (2009). |
| 157. | Soh, Z., Tsuji, T., Takiguchi, N., and Ohtake, H., Neuro-based Olfactory Model for Artificial Organoleptic Tests. Artificial Life and Robotics, 14: 474-479 (2009). |
| 2010- | JUMP TO TOP OF ORIGINAL PAPERS |
| 158. | W.-D. Kim, M. Tokunaga, H. Ozaki, T. Ishibashi, K. Honda, H. Kajiura, K.Fujiyama,R.Asano,
I. Kumagai, T. Omasa, and H. Ohtake Glycosylation pattern of humanized IgG-like bispecific 1 antibody produced by recombinant CHO cells. Appl. Microbiol. Biotechnol., 85:535?542 (2010). |
| 159. | Tsuji, T., Suzuki, M., Takiguchi, N., and Ohtake, H. Biomimetic control based on a model of chemotaxis in Escherichia coli. Artificial Life, 16(2): 155-177 (2010). |
| 160. | Hirota, R., Kuroda, A., Kato, J. and Ohtake, H. Bacterial phosphate metabolism and its use for phosphorus recycling and industrial bioprocesses (Review). J. Biosc. Bioeng., 109: 423-432 (2010). |
| 161. | Park, J.-Y., Takagi, Y., Yamatani, M., Honda, K., Asakawa, S., Shimizu,
N., Omasa T., and Othake, H. Identification and analysis of specific chromosomal region adjacent to exogenous Dhfr-amplified region in Chinese hamster ovary genome. J. Biosc. Bioeng., 504-511 (2010). |
| 162. | Zhou, Y., Minami, T., Honda, K., Omasa, T., and Ohtake, H. Systematic screening of Escherichia coli single-gene knockout mutants for improving recombinant whole-cell catalysts. Appl. Microbiol. Biotechnol., 87: 647-655 (2010). |
| 163. | Park, J.-Y., Yamatani, M., Wadano, S., Takagi, Y., Honda, K., Omasa T.,
and Othake, H. Effects of palindrome structure on Dhfr amplification in Chinese hamster ovary cells. Process Biochem., 45: 1845-1851 (2010). |
| 164. | Kashihara, H., Kang, B., Omasa, T., Honda, K., Sameshima, Y., Kuroda, A.,
and Ohtake, H. Electron microscopic analysis of heat-induced leakage of polyphosphate from a phoU mutant of Escherichia coli. Biosci., Biotechnol. Biochem., 74: 865-868 (2010) |
| 165. | Zhou Y., Minami, T., Honda, K., Omasa, T. and Ohtake, H. Enhancement of recombinant enzyme activity in cpxA-deficient mutant of Escherichia coli. J. Biosc. Bioeng., 110: 403-407 (2010). |
| 166. | Honda, K., Maya, S., Omasa, T., Hirota, R., Kuroda, A., and Ohtake, H. Production of 2-deoxyribose 5-phosphate from fructose to demonstrate a potential of artificial bio-synthetic pathway using thermophilic enzymes. J. Biotechnol., 148: 204-207 (2010). |
| 167. | Cappelletti, M., Fedi, S., Frascari, D., Ohtake, H., Turner, R.J., and Zannoni, D. Analyses of both the alkB gene transcriptional start site and alkB promoter inducing properties in Rhodococcus sp. BCP1 as grown on n-alkanes. Appl. Environ. Microbiol., 77:1619-1627(2011) |
| 168. | Zu Soh, Toshio Tsuji, Noboru Takiguchi, and Hisao Ohtake. An artificial neural network approach for glomerular activity pattern prediction using the graph kernel method and the Gaussian mixture functions. Chem. Senses, 36:413-424(2011) |
| 169. | Izawa, N., Serata, M., Sone, T., Omasa, T., and Ohtake, H. Hyaluronic acid production by recombinant Streptococcus thermophilus. J. Biosc. Bioeng., 111:665-670(2011) |
| 170. | Kang, B., Honda, K., Aki, T., Omasa, T., and Ohtake, H. Simultaneous thermogravimetric and differential thermal analysis of microorganims for assessing their burning characteristics. Thermochimica Acta, 517:115-120(2011) |
| 171. | Motomura, K., Hirota, R., Ohnaka, N., Okada, M., Ikeda, T., Morohoshi,
M., Ohtake, H. and Kuroda, K. Overproduction ofYjbB reduces the level of polyphosphate in Escherichia coli : a hypothetical role of YjbB in phosphate export and polyphosphate accumulation. FEMS Microbiol. Lett.,320: 25-32 (2011). |
| 172. | Restiawaty, E., Iwasa, Y., Maya, S., Honda, K., Omasa, T., Hirota, R.,
Kuroda, A., and Ohtake, H. Feasibility of thermophilic ATP regeneration system using Thermus thermophilus polyphosphate kinase. Process Biochemistry, 46：1747-1752 (2011). |
| 173. | Kang, B., Honda, K., Okano, K., Aki, T., Omasa, T. and Ohtake, H. Thermal analysis for differentiating between oleaginous and non-oleaginous microorganisms. Biochem. Eng. J., 57: 23-27 (2011). |
| 174. | N. Wangthamrongwit, K. Klinsakul, A. S. Vangnai, J. Wongkongkatep, P. Inprakhon,
K. Honda, H. Ohtake, J. Kato and T. Pongtharangkul Bioproduction of Vanillin using an Organic Solvent-tolerant Brevibacillus agri 13. Appl. Microbiol. Biotechnol., 93: 555-563 (2012). |
| 175. | Cao,Y., Kimura, S., Itoi, T., Honda, K., Ohtake, H., Omasa, T. Construction of BAC-based physical map and analysis of chromosome rearrangement in Chinese hamster ovary cell lines. Biotechnol. Bioeng, 109: 1357-1367 (2012). |
| 176. | Y.Cao, S. Kimura, T. Itoi, K. Honda, H. Ohtake, T. Omasa Fluorescence in situ hybridization using bacterial artificial chromosome (BAC) clones for the analysis of chromosome rearrangement in Chinese hamster ovary cells. Methods,56: 418-423 (2012). |
| 177. | E. Restiawaty, K. Honda, K. Okano, R. Hirota, T. Omasa, A. Kuroda, H. Ohtake Construction of membrane-anchoring fusion protein of Thermococcus kodakaraensis KOD1glycerol kinase and its application to repetitive batchwise reactions. J. Biosc. Bioeng.,113: 521-525 (2012). |
| 178. | Onitsuka, M., Kim, W.-D., Ozaki, H., Kawaguchi, A., Honda, K., Kajiura,
H., Fujiyama, K., Asano, R., Kumagai, I., Ohtake, H., and Omasa, T. Enhancement of sialylation on humanized IgG-like bispecific antibody by overexpression of a2,6-sialyltransferase derived from Chinese hamster ovary cells. Appl. Microbiol. Biotechnol., 94: 69-80 (2012). |
| 179. | Siriphongphaew, A., Pisnupong, P., Wongkongkatep, J., Inprakhon, P., Vangnai,
A. Honda, K.., Ohtake, H., Kato, J., Ogawa, J., Shimizu, S., Ulracher, V., Schmid, R., and Pongtharangkul, T. Development of a whole-cell biocatalyst co-expressing the P450 monooxygenase a nd glucose dehydrogenase for synthesis of epoxyhexane. Appl. Microbiol. Biotechnol., 95: 357-367 (2012).. |
| 180. | Honda, K., Imura, M., Okano, K., Omasa, T., Kato, J., and Ohtake, H. (2012) Identification of the replicon of 111-kb circular plasmid from
Rhodococcus opacus B-4. Biosci. Biotechnol. Biochem., 76, 1758-1764.(2012). |
| 181. | Ye, X., Honda, K., Sakai, T., Okano, K., Omasa, T., Hirota, R., Kuroda,
A. and Ohtake, H. (2012) Synthetic metabolic engineering-a novel technology for designing
a chimeric metabolic pathway. Microbial Cell Fact. 11, 120.(2012). |
| 182. | Ye, X., Honda, K., Morimoto, Y., Okano, K. and Ohtake, H. (2013) Direct conversion of glucose to malate by synthetic metabolic
engineering. J. Biotechnol.164,34-40.(2013). |
| 183. | Ninh, P.H., Honda, K., Yokohigashi, Y., Okano, K., Omasa, T. and Ohtake, H. (2013) Development of continuous bioconversion system using thermophilic whole-cell biocatalyst. Appl. Environ. Microbiol. 79: 1996-2001 (2013). |
| 184. | Okano, K., Uemoto, M., Kagami, J., Miura, K., Aketo, T., Toda, M., Honda,
K. and Ohtake, H. (2013) Novel technique for phosphorus recovery from aqueous solutions
using amorphous calcium silicate hydrates (A-CSHs). Water Res. 47,2251-2259.(2013) |
| 185. | Hibino, A. and Ohtake, H. Utilization of hydrophobic bacterium Rhodococcus rhodochrous NBRC15564 as whole-cell catalyst in solvent-free organic media. Process Biochem., 48:838-843(2013) |
| 186. | Hibino, A., Petri, R., Büchs, J., and Ohtake, H. Production of uroporphyrinogen III from 5-aminolevulinic acid using Escherichia coli expressing thermostable enzymes Appl. Microbiol. Biotechnol., 97:7337-7344(2013) |
| 187. | Lee, K-H., Onitsuka, M., Honda, K., Ohtake, H. and Omasa, T. Rapid Construction of Transgene-amplified CHO Cell Lines by Cell Cycle Checkpoint Engineering. Appl. Microbiol. Biotechnol., 97:5731-5141(2013) |
| 188. | Haredy, A.M. Takenaka, N., Yamada, H., Sakoda, Y., Okamatsu, M., Yamamoto,
N., Omasa, T., Ohtake, H., Mori, Y., Kida, H., Yamanishi, K., Okamoto, S. MDCK cell culture-derived formalin-inactivated influenza whole virion vaccine from an influenza virus library conferred cross-protective immunity by intranasal administration in mice. Clinic. Vacci. Immunol., in press. |
| 189. | Lee, K-H., Tsutsui, T., Honda, K., Asano, R., Kumagai, I., Ohtake, H. and Omasa, T. Generation of High-producing Cell Lines by Overexpression of Cell Division Cycle 25 Homolog A in Chinese Hamster Ovary Cells. J. Biosc. Bioeng., 116: 754-760 (2013). |
| 190. | Morimoto, Y., Honda, K., Ye X., Okano, K., and Ohtake, H. Directed evolution of thermotolerant malic enzyme for improved malate production. J. Biosc. Bioeng., 117,147-152（2013） |
| 191. | Krutsakorn, B., Honda, K., Ye, X., Imagawa, T., Bei, X., Okano, K., and
Ohtake, H. In vitro production of n-butanol from glucose. Metabolic Eng.,20: 84-91 (2013). |
| 192. | Krutsakorn, B., Imagawa, T., Honda, K., Okano, K., and Ohtake, H. Construction of an in vitro bypassed pyruvate decarboxylation pathway using thermostable enzyme modules and its application to N-acetylglutamate production. Microb. Cell Fact., 12,91(2013） |
| 193. | Haredy, A.M., Nishizawa, A., Honda, K., Ohya, T., Ohtake, H. and Omasa, T. Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression. Cytotechnology, 65: 993-1002 (2013). |
| 194. | Lee, K.H., Tsutsui, T., Honda, K., Ohtake, H., Omasa, T. Overexpression of Mutant Cell Division Cycle 25 Homolog B enhances the Efficiency of Gene Amplification in Chinese Hamster Ovary Cells. Cytotechnology, 65: 1017-1026 (2013). |
| 195. | Onitsuka, M., Kawaguchi, A., Asano, R., Kumagai, I., Honda, K., Ohtake, H., and Omasa, T. Glycosylation analysis of an aggregated antibody produced by Chinese hamster ovary cells in bioreactor culture. J. Biosc. Bioeng., 117, 639-644.(2014) |
| 196. | Tsuji, N., Honda, K., Wada, M., Okano, K., and Ohtake, H. Isolation and characterization of a thermotolerant ene reductase from Geobacillus sp. 30 and its heterologous expression in Rhodococcus opacus. Appl. Microb. Biotechnol., 98: 5925-5935(2014) |
| 197. | Ninh, P.H., Honda, K., Sakai, T., Okano, K., Ohtake, H. Assembly and multiple gene expression of thermophilic enzymes in Escherichia coli for in vitro metabolic engineering. Biotechnol. Bioeng.in press |
| 12 August, 2014 | |
バナースペース
OHTAKE LAB
Biochemical Engineering Lab
Dept.of Biotechnology
Graduate School of Engineering,
Osaka University
Yamadaoka 2-1, Suita Osaka
565-0871 Japan
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